333 research outputs found
Association between monosodium glutamate intake and sleep-disordered breathing among Chinese adults with normal body weight
ObjectiveTo assess whether monosodium glutamate (MSG) intake is associated with sleep-disordered breathing (SDB).MethodsData from 1227 Chinese subjects who participated in the Jiangsu Nutrition Study were analyzed. All the participants were examined at two time points (baseline in 2002 and follow-up in 2007). The MSG intake was assessed quantitatively in 2002 and a sleep questionnaire was used to assess snoring and to construct an SDB probability score in 2007. Those within the fifth quintile of the score (highest) were defined as having a high probability of SDB.ResultsThe MSG intake was positively associated with snoring and a high probability of SDB in participants who had a normal body weight but in those who were overweight. A comparison of the extreme quartiles of MSG intake in subjects with a body mass index lower than 23 kg/m² showed an odds ratio of 2.02 (95% confidence interval 1.02-4.00) for snoring and an odds ratio of 3.11 (95% confidence interval 1.10-8.84) for a high probability of SDB. There was a joint effect between MSG and overweight in relation to SDB.ConclusionThe intake of MSG may increase the risk of SDB in Chinese adults with a normal body weight.Zumin Shi, Gary A. Wittert, Baojun Yuan, Yue Dai, Tiffany K. Gill, Gang Hu, Robert Adams, Hui Zuo, Anne W. Taylo
Ultra High Energy Cosmic Rays from Cosmological Relics
The current status of origin of Ultra High Energy Cosmic Rays (UHECR) is
reviewed, with emphasis given to elementary particle solutions to UHECR
problem, namely to Topological Defects and Super-Heavy Dark Matter (SHDM)
particles. The relic superheavy particles are very efficiently produced at
inflation. Being protected by gauge discrete symmetries, they can be long
lived. They are clustering in the Galactic halo, producing thus UHECR without
Greisen-Zatsepin-Kuzmin cutoff. Topological Defects can naturally produce
particles with energies as observed and much higher, but in most cases fail to
produce the observed fluxes. Cosmic necklaces, monopoles connected by strings
and vortons are identified as most plausible sources. The latter two of them
are also clustering in the halo and their observational predictions are
identical to those of SHDM particles.Comment: Invited talk at TAUP-99, Paris, September 6 - 10, 1999. Several
references are adde
Post-traumatic stress disorder following childbirth: an update of current issues and recommendations for future research
Objective:
This paper aimed to report the current status of research in the field of post-traumatic stress disorder following childbirth (PTSD FC), and to update the findings of an earlier 2008 paper.
Background:
A group of international researchers, clinicians and service users met in 2006 to establish the state of clinical and academic knowledge relating to PTSD FC. A paper identified four key areas of research knowledge at that time.
Methods:
Fourteen clinicians and researchers met in Oxford, UK to update the previously published paper relating to PTSD FC. The first part of the meeting focused on updating the four key areas identified previously, and the second part on discussing new and emerging areas of research within the field.
Results:
A number of advances have been made in research within the area of PTSD FC. Prevalence is well established within mothers, several intervention studies have been published, and there is growing interest in new areas: staff and pathways; prevention and early intervention; impact on families and children; special populations; and post-traumatic growth.
Conclusion:
Despite progress, significant gaps remain within the PTSD FC knowledge base. Further research continues to be needed across all areas identified in 2006, and five areas were identified which can be seen as ‘new and emerging’. All of these new areas require further extensive research. Relatively little is still known about PTSD FC
Ultra High Energy Cosmic Rays
The current status of Ultra High Energy Cosmic Rays (UHECR) is reviewed, with
emphasis given to theoretical interpretation of the observed events. The
galactic and extragalactic origin, in case of astrophysical sources of UHE
particles, have the problems either with acceleration to the observed energies
or with the fluxes and spectra. Topological defects can naturally produce
particles with energies as observed and much higher, but in most cases fail to
produce the observed fluxes. Cosmic necklaces and monopole-antimonopole pairs
are identified as most plausible sources, which can provide the observed flux
and spectrum. The relic superheavy particles are shown to be clustering in the
Galactic halo, producing UHECR without Greisen-Zatsepin-Kuzmin cutoff. The
Lightest Supersymmetric Particles are discussed as UHE carriers in the
Universe.Comment: 10 pages text, 6 ps figures, 1 jpeg figure. Invited talk at TAUP-9
The epidemiology of injuries across the weight-training sports
Background: Weight-training sports, including weightlifting, powerlifting, bodybuilding, strongman, Highland Games, and CrossFit, are weight-training sports that have separate divisions for males and females of a variety of ages, competitive standards, and bodyweight classes. These sports may be considered dangerous because of the heavy loads commonly used in training and competition. Objectives: Our objective was to systematically review the injury epidemiology of these weight-training sports, and, where possible, gain some insight into whether this may be affected by age, sex, competitive standard, and bodyweight class. Methods: We performed an electronic search using PubMed, SPORTDiscus, CINAHL, and Embase for injury epidemiology studies involving competitive athletes in these weight-training sports. Eligible studies included peer-reviewed journal articles only, with no limit placed on date or language of publication. We assessed the risk of bias in all studies using an adaption of the musculoskeletal injury review method. Results: Only five of the 20 eligible studies had a risk of bias score ≥75 %, meaning the risk of bias in these five studies was considered low. While 14 of the studies had sample sizes >100 participants, only four studies utilized a prospective design. Bodybuilding had the lowest injury rates (0.12–0.7 injuries per lifter per year; 0.24–1 injury per 1000 h), with strongman (4.5–6.1 injuries per 1000 h) and Highland Games (7.5 injuries per 1000 h) reporting the highest rates. The shoulder, lower back, knee, elbow, and wrist/hand were generally the most commonly injured anatomical locations; strains, tendinitis, and sprains were the most common injury type. Very few significant differences in any of the injury outcomes were observed as a function of age, sex, competitive standard, or bodyweight class. Conclusion: While the majority of the research we reviewed utilized retrospective designs, the weight-training sports appear to have relatively low rates of injury compared with common team sports. Future weight-training sport injury epidemiology research needs to be improved, particularly in terms of the use of prospective designs, diagnosis of injury, and changes in risk exposure
Signatures of Topological Defects
We argue that due to various restrictions cosmic strings and monopole-string
networks are not likely to produce the observed flux of ultra-high energy
cosmic rays (UHECR). Among the topological defects studied so far, the most
promising UHECR sources are necklaces and monopolonia. Other viable sources
which are similar to topological defects are relic superheavy particles. All
these sources have an excess of pions (and thus photons) over nucleons at
production. We demonstrate that in the case of necklaces the diffuse proton
flux can be larger than photon flux, due to absorption of the latter on
radiobackground, while monopolonia and relic particles are concentrated in the
Galactic halo, and the photon flux dominates. Another signature of the latter
sources is anisotropy imposed by asymmetric position of the sun in the Galactic
halo. In all cases considered so far, including necklaces, photons must be
present in ultra-high energy radiation observed from topological defects, and
experimental discrimination between photon-induced and proton-induced extensive
air showers can give a clue to the origin of ultra-high energy cosmic rays.Comment: version accepted for publication in Phys. Rev. D. No changes in the
conclusions and in figure
Prevalence and impact of alcohol and other drug use disorders on sedation and mechanical ventilation: a retrospective study
BACKGROUND: Experience suggests that patients with alcohol and other drug use disorders (AOD) are commonly cared for in our intensive care units (ICU's) and require more sedation. We sought to determine the impact of AOD on sedation requirement and mechanical ventilation (MV) duration. METHODS: Retrospective review of randomly selected records of adult patients undergoing MV in the medical ICU. Diagnoses of AOD were identified using strict criteria in Diagnostic and Statistical Manual of Mental Disorders, and through review of medical records and toxicology results. RESULTS: Of the 70 MV patients reviewed, 27 had AOD (39%). Implicated substances were alcohol in 22 patients, cocaine in 5, heroin in 2, opioids in 2, marijuana in 2. There was no difference between AOD and non-AOD patients in age, race, or reason for MV, but patients with AOD were more likely to be male (21 versus 15, p < 0.0001) and had a lower mean Acute Physiology and Chronic Health Evaluation II (22 versus 26, p = 0.048). While AOD patients received more lorazepam equivalents (0.5 versus 0.2 mg/kg.day, p = 0.004), morphine equivalents (0.5 versus 0.1 mg/kg.day, p = 0.03) and longer duration of infusions (16 versus 10 hours/day. medication, p = 0.002), they had similar sedation levels (Richmond Agitation-Sedation Scale (RASS) -2 versus -2, p = 0.83), incidence of agitation (RASS ≥ 3: 3.0% versus 2.4% of observations, p = 0.33), and duration of MV (3.6 versus 3.9 days, p = 0.89) as those without AOD. CONCLUSION: The prevalence of AOD among medical ICU patients undergoing MV is high. Patients with AOD receive higher doses of sedation than their non-AOD counterparts to achieve similar RASS scores but do not undergo longer duration of MV
Treatments for people who use anabolic androgenic steroids: a scoping review.
BACKGROUND: A growing body of evidence suggests that anabolic androgenic steroids (AAS) are used globally by a diverse population with varying motivations. Evidence has increased greatly in recent years to support understanding of this form of substance use and the associated health harms, but there remains little evidence regarding interventions to support cessation and treat the consequences of use. In this scoping review, we identify and describe what is known about interventions that aim to support and achieve cessation of AAS, and treat and prevent associated health problems. METHODS: A comprehensive search strategy was developed in four bibliographic databases, supported by an iterative citation searching process to identify eligible studies. Studies of any psychological or medical treatment interventions delivered in response to non-prescribed use of AAS or an associated harm in any setting were eligible. RESULTS: In total, 109 eligible studies were identified, which included case reports representing a diverse range of disciplines and sources. Studies predominantly focussed on treatments for harms associated with AAS use, with scant evidence on interventions to support cessation of AAS use or responding to dependence. The types of conditions requiring treatment included psychiatric, neuroendocrine, hepatic, kidney, cardiovascular, musculoskeletal and infectious. There was limited evidence of engagement with users or delivery of psychosocial interventions as part of treatment for any condition, and of harm reduction interventions initiated alongside, or following, treatment. Findings were limited throughout by the case report study designs and limited information was provided. CONCLUSION: This scoping review indicates that while a range of case reports describe treatments provided to AAS users, there is scarce evidence on treating dependence, managing withdrawal, or initiating behaviour change in users in any settings. Evidence is urgently required to support the development of effective services for users and of evidence-based guidance and interventions to respond to users in a range of healthcare settings. More consistent reporting in articles of whether engagement or assessment relating to AAS was initiated, and publication within broader health- or drug-related journals, will support development of the evidence base
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